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    STMicroelectronics Works with Alifax on Rapid, Cost-Efficient Point-of-Care Medical Testing

    STMicroelectronics (NYSE: STM),a global semiconductor leader serving customers across the spectrum of electronics applications, and Alifax S.r.l, a producer of clinical diagnostic instrumentation, have worked together on a rapid, cost-efficient portable solution that will be available from Alifax, for point-of-care molecular diagnostic detection using highly reliable real-time Polymerase Chain Reactions (PCR) to amplify genetic material (RNA and DNA1) in patient samples.

    Leveraging technology developed and licensed from ST, Alifax is manufacturing the Molecular Mouse, a small portable instrument that contains a broad range of ST components, including STM32 MCUs, sensors, amplifiers, and other devices. Connected to a PC, the Molecular Mouse uses medical reagents2 created by Alifax to manage the control and testing of multiple targets or samples on a tiny disposable cartridge, manufactured by ST using its high-volume Micro-Electro-Mechanical Systems (MEMS) semiconductor process technology. Test results are available in less than an hour.

    “One crucial lesson from the current global pandemic is the importance of rapid, cost-efficient point-of-care testing that allows immediate remote diagnosis, and then, if necessary, patient isolation,” said Alessandro Cremonesi, Chief Innovation Officer, STMicroelectronics. “ST has been investing in its Real-Time PCR platform convinced that innovative semiconductor-based diagnostic solutions can positively impact our lives.“

    “Leveraging our high-volume semiconductor-manufacturing technology and long-term leadership in microfluidics, we’ve developed a rapidly customizable, highly flexible cartridge and instrumentation platform that delivers rapid and precise point-of-care diagnostic results, which Alifax has used to respond almost immediately to present pandemic and future diagnostic needs,” added Benedetto Vigna, President Analog MEMS, and Sensors Group, STMicroelectronics.

    ST has demonstrated its efficacy and efficiency to scale reliable, high-volume manufacturing of semiconductors and its expertise in microfluidics for more than 25 years. Moreover, roughly 10 years of proven success in developing MEMS-based Real-Time PCR technologies has now culminated in a product generation that Alifax has rapidly adapted to address the current global pandemic.

    “Building on our passion for research and excellence in innovation, Alifax has established its strength in hematology and bacteriology for diagnostic purposes. By working closely with ST and combining its foundational microfluidic and other technology in the Molecular Mouse and our pathogen-specific assays, starting from a COVID-19 test, we’re ready to contribute to rapidly diagnosing, isolating, and ultimately stopping the spread of pathogens,” said Paolo Galiano, President Alifax.

    Certified to CE-IVD3 the Molecular Mouse, disposable test cartridges, and assays are available now from Alifax.

    You can watch a video on Molecular Mouse at https://www.alifax.com/products/nuova-category-page/show/molecular-mouse.

    Further Technical Information
    With a footprint4 smaller than a smartphone, the Alifax Molecular Mouse can run real-time quantitative Polymerase Chain Reactions (qPCR) on small disposable cartridges, manufactured by ST using its high-volume semiconductor manufacturing process technology.

    Each cartridge features 6 tiny reaction chambers (for the COVID-19 test, Alifax is using 2 chambers per sample). Each chamber supports precise heating and cooling of the reagents and samples to amplify the target genetic material, if it is present.

    At the same time, exploiting the customized reagents that feature fluorescent tags developed by Alifax specifically to detect COVID-19, the Molecular Mouse determines the presence of the target genetic material in each chamber based on fluorescence intensity on multiple wavelengths.

    For more information, visit www.st.com

    ELE Times Bureau
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